Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow in patients with benign intracranial hypertension (pseudotumor cerebri)
- 1 February 1985
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 17 (2), 158-162
- https://doi.org/10.1002/ana.410170209
Abstract
Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow were investigated in 14 patients with benign intracranial hypertension (pseudotumor cerebri). Intracranial pressure was increased in 9 patients (20 to 30 mm Hg), borderline in 4 patients (15 to 18 mm Hg), and normal in 1 patient (8 mm Hg). Six patients had plateau waves, and all had B waves in more than 50% of the monitored time. Conductance to cerebrospinal fluid outflow, measured by a lumbo‐lumbar perfusion method, was significantly reduced: 0.042 ml·mm Hg−1·min−1 (± 0.004 {SEM}; normal more than 0.080 ml·mm Hg−1·min−1). Cerebral blood flow was measured by xenon 133 inhalation and single photon emission computer tomography. Mean hemispheric flow was normal in all cases, averaging 59 ± 9 ml·100 gm−1·min−1. Only 2 patients showed focal low‐flow areas. Thus, a disturbance of cerebrospinal fluid circulation seems to be of pathogenetic significance in benign intracranial hypertension.Keywords
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