Sarcopenia: Pharmacology of Today and Tomorrow
- 28 August 2012
- journal article
- review article
- Published by American Society for Pharmacology & Experimental Therapeutics (ASPET)
- Vol. 343 (3), 540-546
- https://doi.org/10.1124/jpet.112.191759
Abstract
Sarcopenia remains largely undiagnosed and undertreated because of the lack of a universally accepted definition, effective ways to measure it, and identification of the outcomes that should guide treatment efficacy. An ever-growing number of clinicians and researchers along with funding and regulatory agencies have gradually recognized that sarcopenia is a human condition that requires both prevention and treatment. In this article, we review sarcopenia and its common and less known pharmacological treatments, attempt to define sarcopenia in its broader context, and present some new ideas for potential future treatment for this devastating condition.Keywords
This publication has 74 references indexed in Scilit:
- mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle MassCell Metabolism, 2011
- Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on SarcopeniaJournal of the American Medical Directors Association, 2011
- Hindlimb skeletal muscle function in myostatin‐deficient miceMuscle & Nerve, 2010
- Debio-025 is more effective than prednisone in reducing muscular pathology in mdx miceNeuromuscular Disorders, 2010
- Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse AtrophyJournal of Biological Chemistry, 2010
- Fixing ryanodine receptor Ca2+ leak – a novel therapeutic strategy for contractile failure in heart and skeletal muscleDrug Discovery Today: Disease Mechanisms, 2010
- Sarcopenia: European consensus on definition and diagnosisAge and Ageing, 2010
- Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest oldAge and Ageing, 2010
- New approaches to treatment of primary immunodeficiencies: fixing mutations with chemicalsCurrent Opinion in Allergy and Clinical Immunology, 2008
- Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ releaseThe Journal of cell biology, 2006