Sinonasal Tract Solitary Fibrous Tumor: A Clinicopathologic Study of Six Cases with a Comprehensive Review of the Literature
- 27 December 2017
- journal article
- review article
- Published by Springer Science and Business Media LLC in Head and Neck Pathology
- Vol. 12 (4), 471-480
- https://doi.org/10.1007/s12105-017-0878-y
Abstract
Solitary fibrous tumors (SFTs) are well recognized in the head and neck region, but rarely arise in the sinonasal tract (SNT). Six primary SNT SFTs were identified in the files of Southern California Permanente Medical Group between 2006 and 2017. The patients included five males and one female ranging in age from 33 to 72 years (mean 52 years), most of whom presented clinically with nasal obstruction. Three tumors involved the nasal cavity alone, one involved the paranasal sinuses, and two involved both the nasal cavity and paranasal sinuses. Histologically, the tumors were characterized by a variably cellular proliferation of cytologically bland spindle cells within a collagenous stroma with prominent interspersed branching vessels. Mitotic activity was low (range 0–2 per 10 high power fields) and there was no evidence of pleomorphism or tumor necrosis. Surface ulceration was noted. By immunohistochemistry, the lesional cells were positive for CD34, STAT6 and bcl-2. Clinical follow up information was available for all patients (range 32–102 months; mean 72 months). There were no recurrences or metastases and all were alive with no evidence of disease at last follow-up. SFTs rarely affect the SNT, but should be considered in the differential diagnosis of SNT mesenchymal lesions. Immunohistochemical expression of STAT6 can aid in diagnosis and separation of SFT from other spindle cell lesions occurring at this anatomic site. In combination with cases reported in the literature, primary SNT SFT behave in an indolent manner with conservative treatment.This publication has 100 references indexed in Scilit:
- Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimicsLaboratory Investigation, 2014
- Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumorGenes, Chromosomes and Cancer, 2013
- Poorly differentiated synovial sarcoma of the sphenoid sinus: report of the first case and review of synovial sarcomas of the sinonasal tractHistopathology, 2012
- Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment modelLaboratory Investigation, 2012
- Endoscopic Resection of Solitary Fibrous Tumors of the Nose and Paranasal SinusesJournal of Neurological Surgery Part B: Skull Base, 2011
- Solitary Fibrous Tumor Arising from the Sphenoid SinusCase Reports in Medicine, 2009
- Solitary fibrous tumour of the ethmoid sinuses and anterior fossaBMJ Case Reports, 2009
- Extrapleural Solitary Fibrous Tumor: A Clinicopathologic Study of 19 CasesInternational Journal of Surgical Pathology, 2009
- Malignant Solitary Fibrous Tumor of the Nasal CavityJournal of Neurological Surgery Part B: Skull Base, 2007
- Solitary Fibrous Tumor of the Sinonasal Tract: Case Report and Review of the LiteratureAmerican Journal of Rhinology, 1992