Blocks in Elongation and Initiation of Protein Synthesis Induced by Interferon Treatment in Mouse L Cells
- 1 May 1975
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 54 (1), 1-10
- https://doi.org/10.1111/j.1432-1033.1975.tb04106.x
Abstract
Synthesis of polypeptide chains coded by exogenous messenger RNAs is inhibited in cell-free extracts from interferon-treated mouse L cells, due to a "deficiency" in some specific tRNA species. A detailed analysis shows that polypeptide chain elongation is blocked and incomplete chains are formed. After a few minutes, however, initiation of new polypeptide chains is also blocked. Messenger RNA still binds to ribosomes but initiator Met-tRNA(FMET) binding is inhibited. The block in initiation appears to be secondary to the block in elongation.Keywords
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