Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference: evaluation in 95 patients with lung cancer
- 16 November 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Annals of Nuclear Medicine
- Vol. 25 (2), 109-116
- https://doi.org/10.1007/s12149-010-0442-2
Abstract
The objective of this study was to define the factors that correlate with differences in maximum standardized uptake value (SUVmax) in deep-inspiration breath-hold (DIBH) and free breathing (FB) PET/CT admixed with respiratory gating (RG) PET for reference. Patients (n = 95) with pulmonary lesions were evaluated at one facility over 33 months. After undergoing whole-body PET/CT, a RG PET and FB PET/CT scans were obtained, followed by a DIBH PET/CT scan. All scans were recorded using a list-mode dynamic collection method with respiratory gating. The RG PET was reconstructed using phase gating without attenuation correction; the FB PET was reconstructed from the RG PET sinogram datasets with attenuation correction. Respiratory motion distance, breathing cycle speed, and waveform of RG PET were recorded. The SUVmax of FB PET/CT and DIBH PET/CT were recorded: the percent difference in SUVmax between the FB and DIBH scans was defined as the %BH-index. The %BH-index was significantly higher for lesions in the lower lung area than in the upper lung area. Respiratory motion distance was significantly higher in the lower lung area than in the upper lung area. A significant relationship was observed between the %BH-index and respiratory motion distance. Waveforms without steady end-expiration tended to show a high %BH-index. Significant inverse relationships were observed between %BH-index and cycle speed, and between respiratory motion distance and cycle speed. Decrease in SUVmax of FB PET/CT was due to (1) tumor size, (2) distribution of lower lung, (3) long respiratory movement at slow breathing cycle speeds, and (4) respiratory waveforms without steady end-expiration.Keywords
This publication has 22 references indexed in Scilit:
- Local motion correction for lung tumours in PET/CT—first resultsEuropean Journal of Nuclear Medicine and Molecular Imaging, 2008
- Deep-Inspiration Breath-Hold PET/CT of Lung Cancer: Maximum Standardized Uptake Value Analysis of 108 PatientsJournal of Nuclear Medicine, 2008
- Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitionsEuropean Journal of Nuclear Medicine and Molecular Imaging, 2008
- Respiratory-gated CT as a tool for the simulation of breathing artifacts in PET and PET/CTMedical Physics, 2008
- Respiratory gating in positron emission tomography: A quantitative comparison of different gating schemesMedical Physics, 2007
- Respiratory motion correction for PET oncology applications using affine transformation of list mode dataPhysics in Medicine & Biology, 2006
- Deblurring of breathing motion artifacts in thoracic PET images by deconvolution methodsMedical Physics, 2006
- Lung motion correction on respiratory gated 3-D PET/CT imagesIEEE Transactions on Medical Imaging, 2006
- Four‐dimensional (4D) PET/CT imaging of the thoraxMedical Physics, 2004
- Quantitation of respiratory motion during 4D‐PET/CT acquisitionMedical Physics, 2004