Bladder neck mobility is a heritable trait
Open Access
- 12 January 2005
- journal article
- research article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 112 (3), 334-339
- https://doi.org/10.1111/j.1471-0528.2004.00428.x
Abstract
Objective Congenital connective tissue dysfunction may partly be responsible for female pelvic organ prolapse and urinary incontinence. We undertook a heritability study to determine whether mobility of the bladder neck, one of the main determinants of stress urinary incontinence, is genetically influenced. Design Heritability study using a twin model and structural equation modelling. Setting Queensland Institute of Medical Research, Brisbane, Australia. Population One hundred and seventy‐eight nulliparous Caucasian female twins and their sisters (46 monozygotic pairs, 24 dizygotic pairs and 38 sisters) aged 18–24 years. Methods We performed translabial ultrasound, supine and after bladder emptying, for pelvic organ mobility. Urethral rotation and bladder neck descent were calculated using the best of three effective Valsalva manoeuvres. Main outcome measures Bladder and urethral mobility on Valsalva assessed by urethral rotation, vertical and oblique bladder neck descent. Results Genetic modelling indicated that additive genes accounted for up to 59% of the variance for bladder neck descent. All remaining variance appeared due to environmental influences unique to the individual, including measurement error. Conclusion A significant genetic contribution to the phenotype of bladder neck mobility appears likely.Keywords
This publication has 20 references indexed in Scilit:
- Ultrasound imaging of the pelvic floor. Part II: three‐dimensional or volume imagingUltrasound in Obstetrics & Gynecology, 2004
- Ultrasound imaging of the pelvic floor. Part I: two‐dimensional aspectsUltrasound in Obstetrics & Gynecology, 2003
- The effect of childbirth on pelvic organ mobilityPublished by Ovid Technologies (Wolters Kluwer Health) ,2003
- Ultrasound in the quantification of female pelvic organ prolapseUltrasound in Obstetrics & Gynecology, 2001
- What predisposes young women to genital prolapse?European Journal of Obstetrics & Gynecology and Reproductive Biology, 1999
- Prevalent urinary incontinence as a correlate of pregnancy, vaginal childbirth, and obstetric techniques.American Journal of Public Health, 1999
- Epidemiology of surgically managed pelvic organ prolapse and urinary incontinenceObstetrics & Gynecology, 1997
- Obstetric practice and the prevalence of urinary incontinence three months after deliveryBJOG: An International Journal of Obstetrics and Gynaecology, 1996
- Behavioral genetic methodsJournal of Personality, 1986
- Model-fitting approaches to the analysis of human behaviourHeredity, 1978