Dietary α-linolenic acid, linoleic acid, and n–3 long-chain PUFA and risk of ischemic heart disease
- 1 October 2011
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 94 (4), 1097-1103
- https://doi.org/10.3945/ajcn.111.018762
Abstract
N-3 (omega-3) PUFA has been proposed as having health-promoting effects, primarily in relation to ischemic heart disease (IHD). Whether these benefits can be achieved by both α-linolenic acid (ALA, 18:3n-3) and n-3 long-chain PUFA (LC-PUFA) is debatable. The objective was to examine the association between ALA intake and risk of IHD in healthy subjects and to see if this was modified by intake of n-3 LC-PUFA or linoleic acid (LA, 18:2 n-6). This was a prospective cohort study of 3277 healthy Danish women and men free of known IHD. Four hundred seventy-one cases of IHD were observed during a median follow-up period of 23.3 y. Higher intake of ALA was not significantly associated with decreased risk of IHD among women or men. Although the HR of IHD was stepwise decreased with increasing ALA intake in men [0.84 (95% CI: 0.62, 1.14) in the medium compared with the lowest tertile (reference) and 0.83 (95% CI: 0.56, 1.24) in the highest compared with the lowest tertile], this change was far from significant (P-trend: 0.39). No evidence of effect modification by n-3 LC-PUFA or LA was observed. High n-3 LC-PUFA intake, in comparison with low intake, was inversely associated with risk of IHD; this trend was significant in women (P = 0.04; HR: 0.62; 95% CI: 0.40, 0.97) but not in men (P = 0.15; HR: 0.74; 95% CI: 0.51, 1.06). No associations were observed between intake of LA and risk of IHD. This study suggests that there is no association between ALA intake and risk of IHD, but a high intake of n-3 LC-PUFA had a significant cardioprotective effect in women.Keywords
This publication has 34 references indexed in Scilit:
- Fish consumption and risk of major chronic disease in menThe American Journal of Clinical Nutrition, 2008
- Predictive values of acute coronary syndrome discharge diagnoses differed in the Danish National Patient RegistryJournal of Clinical Epidemiology, 2008
- α-Linolenic Acid and Risk of Nonfatal Acute Myocardial InfarctionCirculation, 2008
- Fish Intake, Contaminants, and Human HealthJAMA, 2006
- Dietary α-Linolenic Acid Intake and Risk of Sudden Cardiac Death and Coronary Heart DiseaseCirculation, 2005
- Dietary Linolenic Acid Is Inversely Associated With Calcified Atherosclerotic Plaque in the Coronary ArteriesCirculation, 2005
- Dietary Fat and Risk of Coronary Heart Disease: Possible Effect Modification by Gender and AgeAmerican Journal of Epidemiology, 2004
- Assessment of habitual energy and macronutrient intake in adults: comparison of a seven day food record with a dietary history interviewEuropean Journal of Clinical Nutrition, 2002
- Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult malesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994
- Desaturation and chain elongation of n − 3 and n − 6 polyunsaturated fatty acids in the human CaCo-2 cell lineBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993