The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
Open Access
- 12 January 2011
- journal article
- review article
- Published by The Royal Society in Philosophical Transactions B
- Vol. 366 (1561), 9-16
- https://doi.org/10.1098/rstb.2010.0276
Abstract
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundwormCaenorhabditis elegans. This discovery is described here.Keywords
This publication has 43 references indexed in Scilit:
- The genetics of ageingNature, 2010
- Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegansNature, 2008
- The C. elegans TGF-β Dauer Pathway Regulates Longevity via Insulin SignalingCurrent Biology, 2007
- An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegansCurrent Biology, 2007
- New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi ScreenPLoS Genetics, 2005
- The Plasticity of Aging: Insights from Long-Lived MutantsCell, 2005
- daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegansScience, 1997
- A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegansNature, 1996
- The HGF receptor family: unconventional signal transducers for invasive cell growthGenes to Cells, 1996
- A C. elegans mutant that lives twice as long as wild typeNature, 1993