Carbamazepine‐induced drug‐induced hypersensitivity syndrome in a 14‐year‐old Japanese boy
- 1 December 2008
- Vol. 49 (12), 2118-2121
- https://doi.org/10.1111/j.1528-1167.2008.01785.x
Abstract
Drug-induced hypersensitivity syndrome (DIHS) is a life-threatening idiosyncratic drug reaction, and an early accurate diagnosis is essential for its treatment. We describe a 14-year-old boy with localization-related epilepsy, who developed severe adverse cutaneous and systemic reactions after 3 weeks of carbamazepine administration. During the course of the clinical symptoms, reactivation of human herpesvirus 6 (HHV-6) was proven by detection of the HHV-6 genome in serum and elevation of HHV-6 immunoglobulin G (IgG). He fulfilled the newly established criteria for DIHS. Among eight identified medications that can precipitate DIHS, four are antiepileptic drugs. Establishing a treatment strategy for DIHS is warranted to improve its outcome. Therefore, it is important to raise awareness of DIHS among epileptologists.This publication has 11 references indexed in Scilit:
- Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndromeBritish Journal of Dermatology, 2007
- Idiosyncratic Adverse Reactions to Antiepileptic DrugsEpilepsia, 2007
- The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivationsBritish Journal of Dermatology, 2007
- Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndromeBritish Journal of Dermatology, 2006
- Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?British Journal of Dermatology, 2006
- Drug-induced Hypersensitivity Syndrome(DIHS): A Reaction Induced by a Complex Interplay among Herpesviruses and Antiviral and Antidrug Immune ResponsesAllergology International, 2006
- Association Between Anticonvulsant Hypersensitivity Syndrome and Human Herpesvirus 6 Reactivation and HypogammaglobulinemiaArchives of Dermatology, 2004
- Anticonvulsant Hypersensitivity SyndromePediatric Dermatology, 2002
- Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS)Seminars in Cutaneous Medicine and Surgery, 1996