Immunoglobulin A and liver diseases
Open Access
- 26 October 2017
- journal article
- review article
- Published by Springer Science and Business Media LLC in The Esophagus
- Vol. 53 (6), 691-700
- https://doi.org/10.1007/s00535-017-1400-8
Abstract
Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development. The liver is the front-line organ that receives gut-derived products through the portal vein, implying that the liver could be severely affected by a disrupted intestinal homeostasis. Indeed, some liver diseases like alcoholic liver disease are associated with an altered composition of gut microbiota and increased blood endotoxin levels. Therefore, deficiency of SIgA function appears as a significant factor for the pathogenesis of liver diseases associated with altered gut microbiome. In this review, we describe SIgA functions on the gut microbiome and discuss the role of IgA for liver diseases, especially alcoholic liver disease and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.Keywords
Funding Information
- Japan Society for the Promotion of Science (17K15953)
- National Institute on Alcohol Abuse and Alcoholism (R01 AA020703, U01 AA24726, U01 AA021856)
- Biomedical Laboratory Research and Development, VA Office of Research and Development (I01BX002213)
This publication has 121 references indexed in Scilit:
- A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease PhenotypesGastroenterology, 2010
- Enteric dysbiosis associated with a mouse model of alcoholic liver diseaseJournal of Hepatology, 2010
- Selective IgA DeficiencyJournal of Clinical Immunology, 2010
- High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of ObesityGastroenterology, 2009
- c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in MiceGastroenterology, 2009
- Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot studyAlcohol, 2008
- A core gut microbiome in obese and lean twinsNature, 2008
- Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitisJournal of Hepatology, 2007
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006
- Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant miceProceedings of the National Academy of Sciences of the United States of America, 2006