BASOPHILS IN ALLERGEN-INDUCED PATCH TEST SITES IN ATOPIC DERMATITIS
- 1 January 1982
- journal article
- research article
- Published by Elsevier BV in The Lancet
- Vol. 319 (8264), 127-130
- https://doi.org/10.1016/s0140-6736(82)90379-8
Abstract
Atopic dermatitis often occurs in patients who have high, IgE levels and positive immediate skin tests to several common allergens. However, there is considerable doubt about the role played by allergens in this disease. Patch testing for 48 h at superficially abraded skin sites revealed that allergens could induce eczematous lesions in atopic dermatitis patients but only in those who also gave a positive immediate skin reaction to the same allergen. Lesions induced by the purified house dust mite antigen, antigen P1 contained mononuclear cells, basophils, eosinophils, and neutrophils. These patients also had raised specific serum IgE against antigen P1, and their leucocytes released histamine upon exposure to the same antigen. Thus an acute eczematous lesion can be induced by the application of inhalant allergens to the skin.This publication has 16 references indexed in Scilit:
- Mite faeces are a major source of house dust allergensNature, 1981
- Serum IgE in dermatitis and dermatosis: an analysis of 497 casesArchives of Dermatology, 1977
- The Structure Of Normal Skin And The Morphology Of Atopic EczemaJournal of Investigative Dermatology, 1976
- The Functions And Measurement Of Human B- And T-LymphocytesJournal of Investigative Dermatology, 1976
- The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.JCI Insight, 1976
- Atopic disease and serum immunoglobulin-EBritish Journal of Dermatology, 1975
- CELL-MEDIATED (DELAYED) HYPERSENSITIVITY IN PATIENTS WITH SUMMER HAY-FEVERThe Lancet, 1969
- STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENAThe Journal of Experimental Medicine, 1964
- Importance of Inhalant Allergens in Atopic Dermatitis**From the Allergy Clinic, Temple University Hospital and Medical School, Philadelphia, Penna.Journal of Investigative Dermatology, 1949
- Sensitivity to house dust and goose feathers in infantile eczema: The roˆle of specific allergensJournal of Allergy, 1937