Highly resolved chemical imaging of living cells by using synchrotron infrared microspectrometry
Open Access
- 28 April 1998
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 95 (9), 4837-4840
- https://doi.org/10.1073/pnas.95.9.4837
Abstract
Using synchrotron radiation as an ultra-bright infrared source, we have been able to map the distributions of functional groups such as proteins, lipids, and nucleic acids inside a single living cell with a spatial resolution of a few microns. In particular, we have mapped the changes in the lipid and protein distributions in both the final stages of cell division and also during necrosis.Keywords
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