Viruses with More Than 1,000 Genes: Mamavirus, a New Acanthamoeba polyphagamimivirus Strain, and Reannotation of Mimivirus Genes
Open Access
- 1 January 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Genome Biology and Evolution
- Vol. 3, 737-742
- https://doi.org/10.1093/gbe/evr048
Abstract
The genome sequence of the Mamavirus, a new Acanthamoeba polyphaga mimivirus strain, is reported. With 1,191,693 nt in length and 1,023 predicted protein-coding genes, the Mamavirus has the largest genome among the known viruses. The genomes of the Mamavirus and the previously described Mimivirus are highly similar in both the protein-coding genes and the intergenic regions. However, the Mamavirus contains an extra 5′-terminal segment that encompasses primarily disrupted duplicates of genes present elsewhere in the genome. The Mamavirus also has several unique genes including a small regulatory polyA polymerase subunit that is shared with poxviruses. Detailed analysis of the protein sequences of the two Mimiviruses led to a substantial amendment of the functional annotation of the viral genomes.Keywords
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