Effect of magnesium supplementation on blood pressure: a meta-analysis
- 8 February 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Nutrition
- Vol. 66 (4), 411-418
- https://doi.org/10.1038/ejcn.2012.4
Abstract
To date, there has been inconclusive evidence regarding the effect of magnesium supplements on blood pressure (BP). This meta-analysis was conducted to assess the effect of magnesium supplementation on BP and to establish the characteristics of trials showing the largest effect size. Primary outcome measures were systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the end of the follow-up period. One hundred and forty-one papers were identified, of which 22 trials with 23 sets of data (n=1173), with 3 to 24 weeks of follow-up met the inclusion criteria, with a supplemented elemental magnesium range of 120???973???mg (mean dose 410???mg). 95% confidence intervals (CI) were calculated using DerSimonian and Laird's random-effects model, with effect size calculated using Hedges G. Combining all data, an overall effect of 0.36 and 0.32 for DBP and SBP, respectively, was observed (95% CI 0.27???0.44 for DBP and 0.23???0.41 for SBP), with a greater effect being seen for the intervention in crossover trials (DBP 0.47, SBP 0.51). Effect size increased in line with increased dosage. Although not all individual trials showed significance in BP reduction, combining all trials did show a decrease in SBP of 3???4???mm???Hg and DBP of 2???3???mm???Hg, which further increased with crossover designed trials and intake >370???mg/day. To conclude, magnesium supplementation appears to achieve a small but clinically significant reduction in BP, an effect worthy of future prospective large randomised trials using solid methodologyKeywords
This publication has 33 references indexed in Scilit:
- The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trialJournal of Human Hypertension, 2008
- Global burden of blood-pressure-related disease, 2001The Lancet, 2008
- Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetesCurrent Opinion in Lipidology, 2008
- Exercise and hypertensionJournal of Human Hypertension, 2005
- Magnesium and ExerciseCritical Reviews in Food Science and Nutrition, 2002
- Effects of Magnesium Supplementation in Hypertensive PatientsHypertension, 1998
- Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: The aric studyJournal of Clinical Epidemiology, 1995
- Introduction: Importance of Mg in physiology and medicine and the need for ion selective electrodesScandinavian Journal of Clinical and Laboratory Investigation, 1994
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986
- Effect of magnesium supplementation on blood pressure and electrolyte concentrations in hypertensive patients receiving long term diuretic treatment.BMJ, 1986