Acoustic streaming vortices enable contactless, digital control of droplets
Open Access
- 12 June 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 6 (24), eaba0606
- https://doi.org/10.1126/sciadv.aba0606
Abstract
Advances in lab-on-a-chip technologies are driven by the pursuit of programmable microscale bioreactors or fluidic processors that mimic electronic functionality, scalability, and convenience. However, few fluidic mechanisms allow for basic logic operations on rewritable fluidic paths due to cross-contamination, which leads to random interference between “fluidic bits” or droplets. Here, we introduce a mechanism that allows for contact-free gating of individual droplets based on the scalable features of acoustic streaming vortices (ASVs). By shifting the hydrodynamic equilibrium positions inside interconnected ASVs with multitonal electrical signals, different functions such as controlling the routing and gating of droplets on rewritable fluidic paths are demonstrated with minimal biochemical cross-contamination. Electrical control of this ASV-based mechanism allows for unidirectional routing and active gating behaviors, which can potentially be scaled to functional fluidic processors that can regulate the flow of droplets in a manner similar to the current in transistor arrays.Funding Information
- National Science Foundation (ECCS-1807601)
- National Institutes of Health (R01GM132603)
- National Institutes of Health (UG3TR002978)
- National Institutes of Health (R01HD086325)
- National Institutes of Health (R33CA223908)
- National Institutes of Health (R01GM127714)
- U.S. Army Medical Research Acquisition Activity (W81XWH-18-1-0242)
This publication has 40 references indexed in Scilit:
- Ionic-surfactant-mediated electro-dewetting for digital microfluidicsNature, 2019
- Holographic acoustic tweezersProceedings of the National Academy of Sciences of the United States of America, 2018
- Acoustic tweezers for the life sciencesNature Methods, 2018
- Synchronous universal droplet logic and controlNature Physics, 2015
- Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activityLab on a Chip, 2009
- Putting Electrowetting to WorkScience, 2008
- On-chip manipulation of free dropletsNature, 2003
- Electrowetting-based actuation of liquid droplets for microfluidic applicationsApplied Physics Letters, 2000
- Compact acoustic levitation device for studies in fluid dynamics and material science in the laboratory and microgravityReview of Scientific Instruments, 1985
- The Transistor, A Semi-Conductor TriodePhysical Review B, 1948