Noradrenaline and cortisol changes in response to low-grade cognitive stress differ in migraine and tension-type headache
Open Access
- 11 June 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in The Journal of Headache and Pain
- Vol. 8 (3), 157-166
- https://doi.org/10.1007/s10194-007-0384-9
Abstract
The goal of this study was to explore the relationship between indicators of sympathoneural, sympathomedullar and hypothalamic-pituitary-adrenocortical (HPA) activity and stress-induced head and shoulder-neck pain in patients with migraine or tension-type headache (TTH). We measured noradrenaline, adrenaline and cortisol levels before and after low-grade cognitive stress in 21 migraineurs, 16 TTH patients and 34 controls. The stressor lasted for 60 min and was followed by 30 min of relaxation. Migraine patients had lower noradrenaline levels in blood platelets compared to controls. Pain responses correlated negatively with noradrenaline levels, and pain recovery correlated negatively with the cortisol change in migraineurs. TTH patients maintained cortisol secretion during the cognitive stress as opposed to the normal circadian decrease seen in controls and migraineurs. There may therefore be abnormal activation of the HPA axis in patients with TTH when coping with mental stress, but no association was found between pain and cortisol. A relationship between HPA activity and stress in TTH patients has to our knowledge not been reported before. In migraine, on the other hand, both sympathoneural activation and HPA activation seem to be linked to stress-induced muscle pain and recovery from pain respectively. The present study suggests that migraineurs and TTH patients cope differently with low-grade cognitive stress.Keywords
This publication has 39 references indexed in Scilit:
- Stress-Induced Pain and Muscle Activity in Patients with Migraine and Tension-Type HeadacheCephalalgia, 2006
- Acute Stressors and Cortisol Responses: A Theoretical Integration and Synthesis of Laboratory Research.Psychological Bulletin, 2004
- How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative ActionsEndocrine Reviews, 2000
- Plasma Monoamines in Tension-Type HeadacheHeadache: The Journal of Head and Face Pain, 1994
- Catecholamine levels in plasma and CSF in migraine.Journal of Neurology, Neurosurgery & Psychiatry, 1993
- The Relationship Between Perceived Stress, Social Support and Chronic HeadachesHeadache: The Journal of Head and Face Pain, 1993
- Platelet Norepinephrine and Serotonin Balance in MigraineHeadache: The Journal of Head and Face Pain, 1989
- Cardiovascular Sympathetic Hypofunction in Muscle Contraction Headache and MigraineHeadache: The Journal of Head and Face Pain, 1989
- Generation of muscle tension additional to postural muscle loadErgonomics, 1987
- Monoamine oxidase (MAO) activity as a determinant in human neurophysiologyBehavior Genetics, 1982