American Ginseng Berry Juice Intake Reduces Blood Glucose and Body Weight in ob/ob Mice
- 1 October 2007
- journal article
- Published by Wiley in Journal of Food Science
- Vol. 72 (8), S590-S594
- https://doi.org/10.1111/j.1750-3841.2007.00481.x
Abstract
Diabetes is a serious chronic metabolic disease and has a significant impact on patients' lives and the health care system. We previously observed that the organic solvent extract of American ginseng berry possessed significant antidiabetic effects in obese diabetic ob/ob mice after intraperitoneal injection. If American ginseng berry is useful as a dietary supplement, simple preparation and oral intake would be a convenient, safe, and practical means for consumers. In this study, the simply prepared berry juice was first analyzed using high-performance liquid chromatography, and then administered orally in the ob/ob mice. The animals received daily berry juice 0.6 mL/kg or vehicle for 10 consecutive days. The results indicated that oral juice administration significantly lowered fasting blood glucose levels, and this effect continued for at least 10 d after cessation of the treatment. Data from intraperitoneal glucose tolerance test demonstrated that there was a notable improvement in glucose tolerance in the juice treated group. In addition, the berry juice significantly reduced body weight. Our data suggest that ginseng berry juice, as a dietary supplement, may have functional efficacy in consumers with diabetes.Keywords
This publication has 24 references indexed in Scilit:
- Cardiovascular disease prevention in patients with type 2 diabetes: the role of oral anti-diabetic agentsDiabetes and Vascular Disease Research, 2006
- Saponins Composition in American Ginseng Leaf and Berry Assayed by High-Performance Liquid ChromatographyJournal of Agricultural and Food Chemistry, 2006
- Diabetes Mellitus: Pathogenesis and Treatment StrategiesJournal of Medicinal Chemistry, 2004
- Ginseng berry reduces blood glucose and body weight in db/db micePhytomedicine, 2002
- Leptin Reduces Body Weight Gain in Neonatal RatsPediatric Research, 2000
- Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type II Diabetes (VA CSDM): Results of the feasibility trialDiabetes Care, 1995
- Positional cloning of the mouse obese gene and its human homologueNature, 1994
- Clinical review 53: The endocrinology of vasoactive peptides: synthesis to functionJournal of Clinical Endocrinology & Metabolism, 1994
- Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima IndiansThe New England Journal of Medicine, 1993
- Insulin resistance in noninsulin-dependent diabetes mellitus: Does it exist and can it be measured?American Journal Of Medicine, 1983