Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?
Top Cited Papers
Open Access
- 5 January 2016
- journal article
- review article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2016, 1-9
- https://doi.org/10.1155/2016/5698931
Abstract
Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials are so far largely unsuccessful as a preventive or curative measure. Chronic low-grade inflammatory process, on the other hand, plays a central role in the pathogenesis of a number of chronic diseases. Oxidative stress and inflammation are closely related pathophysiological processes, one of which can be easily induced by another. Thus, both processes are simultaneously found in many pathological conditions. Therefore, the failure of antioxidant trials might result from failure to select appropriate agents that specifically target both inflammation and oxidative stress or failure to use both antioxidants and anti-inflammatory agents simultaneously or use of nonselective agents that block some of the oxidative and/or inflammatory pathways but exaggerate the others. To examine whether the interdependence between oxidative stress and inflammation can explain the antioxidant paradox we discussed in the present review the basic aspects of oxidative stress and inflammation and their relationship and dependence.Keywords
This publication has 78 references indexed in Scilit:
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during ApoptosisImmunity, 2012
- Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver DiseaseInternational Journal of Hepatology, 2012
- The InflammasomesCell, 2010
- Vitamins E and C in the Prevention of Cardiovascular Disease in MenJAMA, 2008
- Effect of Combined Folic Acid, Vitamin B6, and Vitamin B12on Cancer Risk in WomenJAMA, 2008
- Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary PreventionJAMA, 2007
- Mechanisms of Disease: oxidative stress and inflammation in the pathogenesis of hypertensionNature Clinical Practice Nephrology, 2006
- Oxidative stress and neurodegeneration: where are we now?Journal of Neurochemistry, 2006
- Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic LifePlant Physiology, 2006
- Measuring reactive species and oxidative damagein vivoand in cell culture: how should you do it and what do the results mean?British Journal of Pharmacology, 2004