Acute Isolated Hyperbilirubinemia as a Presentation of Alcoholic Liver Disease: A Case Report and Literature Review
Open Access
- 12 February 2018
- journal article
- case report
- Published by Hindawi Limited in Case Reports in Hepatology
- Vol. 2018, 1-3
- https://doi.org/10.1155/2018/9403934
Abstract
Isolated hyperbilirubinemia as a manifestation of alcoholic liver disease without significant liver abnormalities is seen very rarely. We report such a case where a patient with chronic alcoholism presented to the ER with acute jaundice with bilirubin of 24.8 mg/dl, predominantly conjugated in nature along with mild elevation of AST (76 IU/L). There were no other abnormalities of the liver function. The patient underwent extensive laboratory and imaging tests that excluded extrahepatic cholestasis, viral and autoimmune hepatitis, ischemic hepatitis, and so forth. Liver biopsy excluded hemochromatosis, dysplasia, or malignancy and other differentials. Bilirubin gradually trended down to 7.3 mg/dl when alcohol consumption was stopped.Keywords
This publication has 14 references indexed in Scilit:
- Diagnosis of Alcoholic Liver DiseaseClinics in Liver Disease, 2016
- Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic ReviewAlcohol: Clinical and Experimental Research, 2016
- Spectrum of Alcoholic Liver DiseaseClinics in Liver Disease, 2016
- Alcohol-induced defects in hepatic transcytosis may be explained by impaired dynein functionMolecular and Cellular Biochemistry, 2014
- Bile Formation and SecretionComprehensive Physiology, 2013
- Drinking habits as cofactors of risk for alcohol induced liver damageGut, 1997
- Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte coupletsThe Journal of Membrane Biology, 1987
- Serum gamma-glutamyl transpeptidase and chronic alcoholismDigestive Diseases and Sciences, 1985
- The SGOT/SGPT ratio?An indicator of alcoholic liver diseaseDigestive Diseases and Sciences, 1979
- Alcohol-Induced Intrahepatic Cholestasis.Annals of Internal Medicine, 1968