Increased rate of respiratory symptoms in children with Down syndrome: a 2-year web-based parent-reported prospective study
Open Access
- 3 October 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Pediatrics
- Vol. 181 (12), 4079-4089
- https://doi.org/10.1007/s00431-022-04634-1
Abstract
To compare the incidence of respiratory symptoms and short-term consequences between children with Down syndrome and children from the general population, we conducted a prospective parent-reported observational study. Children with Down syndrome (≤ 18 years) were included between March 2012 and June 2014. Caregivers received a baseline questionnaire with follow-up 1–2 years after inclusion. Caregivers received a weekly questionnaire about respiratory symptoms, fever, antibiotic prescriptions, doctor’s visits, and consequences for school and work attendance. Children with Down syndrome were compared to a cohort of the general population (“Kind en Ziek” study) with similar weekly questionnaires. A total of 9,011 childweeks were reported for 116 participants with Down syndrome (75% response rate). The frequency of respiratory symptoms was higher in children with Down syndrome than in children from the general population (30% vs 15.2%). In addition, symptoms subsided later (around 8 vs 5 years of age). The seasonal influence was limited, both in children with Down syndrome and children from the general population. Consequences of respiratory disease were significant in children with Down syndrome compared to children from the general population, with a higher rate of doctor’s visits (21.3% vs 11.8%), antibiotic prescriptions (47.8% vs 26.3%), and absenteeism from school (55.5% vs 25.4%) and work (parents, 9.4% vs 8.1%). Conclusion: Children with Down syndrome have a higher frequency of respiratory symptoms and symptoms last until a later age, confirming the impression of professionals and caregivers. Individualized treatment plans might prevent unfavorable consequences of chronic recurrent respiratory disease in children with Down syndrome. What is Known: • Children with Down syndrome have an altered immune system and are prone to a more severe course of respiratory tract infections. • The overall conception is that patients with Down syndrome suffer from respiratory tract infections more often. What is New: • Children with Down syndrome suffer from respiratory symptoms more frequently than children from the general population. • The respiratory symptoms in children with Down syndrome subside at a later age compared to children from the general population.Keywords
This publication has 36 references indexed in Scilit:
- The pot calling the kettle black: the extent and type of errors in a computerized immunization registry and by parent reportBMC Pediatrics, 2014
- An overview of respiratory problems in children with Down's syndromeArchives of Disease in Childhood, 2013
- Infections and immunodeficiency in Down syndromeClinical and Experimental Immunology, 2011
- Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune systemMicrobes and Infection, 2010
- Clinical practiceEuropean Journal of Pediatrics, 2010
- Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndromeEuropean Journal of Pediatrics, 2010
- High Incidence of Recurrent Wheeze in Children With Down Syndrome With and Without Previous Respiratory Syncytial Virus Lower Respiratory Tract InfectionThe Pediatric Infectious Disease Journal, 2010
- Health of Children 3 to 17 Years of Age With Down Syndrome in the 1997–2005 National Health Interview SurveyPEDIATRICS, 2009
- Nasal Ciliary Function and Ultrastructure in Down SyndromeThe Laryngoscope, 2001
- THE RELATIONSHIP OF CONGENITAL HEART DISEASE AND RESPIRATORY INFECTION MORTALITY IN PATIENTS WITH DOWN'S SYNDROMEJournal of Intellectual Disability Research, 1985