Metabolic products of Fusarium larvarum fuckel. The fusarentins and the absolute configuration of monocerin

Abstract

The known fungal metabolites (+)-mellein and monocerin, and the new natural products 7-O-demethylmonocerin, fusarentin 6-methyl ether, fusarentin 6, 7-dimethyl ether, and fusarentin 6, 8-dimethyl ether have been isolated from two strains of the entomogenous fungus Fusarium larvarum grown in surface culture on a synthetic medium. Fusarentin is shown to be (3S)-3, 4-dihydro-6, 7, 8-trihydroxy-3-(2-hydroxy-n-pentyl)isocoumarin and has been related to monocerin, which has the (3aR, 9bR) absolute configuration.