Intravitreal Melphalan for Persistent or Recurrent Retinoblastoma Vitreous Seeds

Abstract

Quiz Ref ID Intravenous chemotherapy (IVC) and intra-arterial chemotherapy (IAC) have improved tumor control in patients with retinoblastoma over the past 2 decades, allowing for dramatic tumor reduction with salvage of the globe, often in an eye that otherwise would have been managed with enucleation.^1-6 Furthermore, there is often some degree of visual acuity retained or regained.^7,8 However, the most challenging aspect of retinoblastoma therapy is control of subretinal or vitreous seeds.^9,10 In general, solid tumors show predictably excellent response to both methods. Subretinal tumor seeds show partial or complete response to either method. Vitreous seeds are the least responsive to IVC or IAC, partly owing to their location in the vitreous remote from blood supply.