The effect of glucagon on serum gastrin: I Studies in normal subjects

Abstract

Serum gastrin has been determined by radioimmunoassay in 13 subjects free of gastrointestinal disease, in the basal state, and following the intravenous injection of 1 mg glucagon. Serum gastrin fell from a mean ± SEM level of 50·3 ± 6·7 to 9·4 ± 3·3 pg/ml at 30 minutes after injection, significant at p<0·005. This is similar to the response previously reported for secretin and indicates a role for glucagon in the control of gastrin release.