Effects of Two Saponins Extracted from the Polygonatum Zanlanscianense Pamp on the Human Leukemia (HL-60) Cells.
- 1 January 2001
- journal article
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 24 (2), 159-162
- https://doi.org/10.1248/bpb.24.159
Abstract
Two saponins, methyl protodioscin and dioscin, were extracted from the root of Polygonatum Zanlanscianense Pamp. One of them, dioscin exerted significant inhibitory effects on the growth of the human leukemia cell HL-60, inducing differentiation and apoptosis. HL60 cells were induced mainly along the granulocytic lineage. In addition, we have found that dioscin affects many cancer cells. These studies may have important significance in treating related cancers.Keywords
This publication has 9 references indexed in Scilit:
- Hypericin Induces Both Differentiation and Apoptosis in Human Promyelocytic Leukemia HL-60 Cells.Biological & Pharmaceutical Bulletin, 1999
- Steroidal Saponins fromAsparagus officinalisand Their Cytotoxic ActivityPlanta Medica, 1997
- Steroid glycosides from Polygonatum prattiiPhytochemistry, 1993
- Steroidal saponins from the rhizomes of Polygonatum orientalePhytochemistry, 1991
- Steroidal Saponins from the Rhizomes of Polygonatum sibiricumJournal of Natural Products, 1990
- UPublished by Walter de Gruyter GmbH ,1986
- Studies on the constituents of palmae plants. III. The constituents of Chamaerops humilis L. and Trachycarpus wagnerianus Becc.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl SulfoxideProceedings of the National Academy of Sciences of the United States of America, 1971
- Detection and Estimation of Steroidal Sapogenins in Plant TissueAnalytical Chemistry, 1952