Dramatic response of metaplastic breast cancer to chemo-immunotherapy
Open Access
- 29 March 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in npj Breast Cancer
- Vol. 3 (1), 1-4
- https://doi.org/10.1038/s41523-017-0011-0
Abstract
Frequent overexpression of programmed death-ligand 1 has recently been demonstrated in metaplastic breast cancer, which is a rare breast cancer subtype with limited treatment options. This report describes the clinical course of a patient with metastatic metaplastic breast cancer who had a remarkable response to anti-programmed death-1 therapy with pembrolizumab in combination with nab-paclitaxel. Tissue correlates are presented including tumor-infiltrating lymphocytes and high-programmed death-ligand 1 expression in the tumor.Keywords
This publication has 14 references indexed in Scilit:
- Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cellsMolecular Cancer, 2015
- Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancerOncotarget, 2015
- Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancerAnnals of Oncology, 2015
- Survival Outcomes of Metaplastic Breast Cancer Patients: Results from a US Population-based AnalysisAnnals of Surgical Oncology, 2014
- PD-L1 Expression in Triple-Negative Breast CancerCancer Immunology Research, 2014
- Mining genome sequencing data to identify the genomic features linked to breast cancer histopathologyJournal of Pathology Informatics, 2014
- CD133 expression associated with poor prognosis in ovarian cancerLaboratory Investigation, 2011
- Metaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transitionLaboratory Investigation, 2011
- Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell CharacteristicsCancer Research, 2009
- Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial–mesenchymal transitionOncogene, 2007