Brain aging and neurodegeneration: from a mitochondrial point of view
Top Cited Papers
Open Access
- 14 May 2017
- journal article
- review article
- Published by Wiley in Journal of Neurochemistry
- Vol. 143 (4), 418-431
- https://doi.org/10.1111/jnc.14037
Abstract
Aging is defined as a progressive time-related accumulation of changes responsible for or at least involved in the increased susceptibility to disease and death. The brain seems to be particularly sensitive to the aging process since the appearance of neurodegenerative diseases, including Alzheimer's disease, is exponential with the increasing age. Mitochondria were placed at the center of the ‘free-radical theory of aging’, because these paramount organelles are not only the main producers of energy in the cells, but also to main source of reactive oxygen species. Thus, in this review, we aim to look at brain aging processes from a mitochondrial point of view by asking: (i) What happens to brain mitochondrial bioenergetics and dynamics during aging? (ii) Why is the brain so sensitive to the age-related mitochondrial impairments? (iii) Is there a sex difference in the age-induced mitochondrial dysfunction? Understanding mitochondrial physiology in the context of brain aging may help identify therapeutic targets against neurodegeneration. This article is part of a series “Beyond Amyloid”.Keywords
Funding Information
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (#31003A_149728)
This publication has 113 references indexed in Scilit:
- Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous RelationshipMolecular Neurobiology, 2012
- Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and agingNeurobiology of Disease, 2011
- Mitochondrial shape changes: orchestrating cell pathophysiologyEMBO Reports, 2010
- Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescenceBiochimica et Biophysica Acta (BBA) - General Subjects, 2010
- Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA MutationsCell, 2010
- Mitochondria in Neuroplasticity and Neurological DisordersNeuron, 2008
- Mitochondrial biogenesis and healthy agingExperimental Gerontology, 2008
- Mitochondrial fragmentation in neurodegenerationNature Reviews Neuroscience, 2008
- Estrogen suppresses brain mitochondrial oxidative stress in female and male ratsBrain Research, 2007
- Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL/6 and DBA/2 miceBrain Research, 2006