Checkpoints of Melanocyte Stem Cell Development
- 23 August 2005
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science's STKE
- Vol. 2005 (298), pe42
- https://doi.org/10.1126/stke.2982005pe42
Abstract
The bulge region of the adult hair follicle contains the niches for both epithelial and melanocyte stem cells. Recent evidence suggests that the development of melanocyte stem cells is controlled by a complex network of transcription factors, including Pax3, Sox10, and Mitf, and of regulatory extracellular cues such as Wnt. However, additional players are likely to be involved. It will be intriguing to identify these signals and to elucidate whether and how neighboring epithelial stem cells influence the balance between melanocyte stem cell maintenance and differentiation.Keywords
This publication has 32 references indexed in Scilit:
- Mammalian Groucho homologs: Redundancy or specificity?Journal of Cellular Biochemistry, 2005
- Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the NicheScience, 2005
- Pax3 functions at a nodal point in melanocyte stem cell differentiationNature, 2005
- Wnt signaling and the regulation of stem cell functionCurrent Opinion in Cell Biology, 2004
- Melanocytes and theMicrophthalmiaTranscription Factor NetworkAnnual Review of Genetics, 2004
- Pluripotent neural crest stem cells in the adult hair follicleDevelopmental Dynamics, 2004
- Lineage-specific requirements of β-catenin in neural crest developmentThe Journal of cell biology, 2002
- Dominant role of the niche in melanocyte stem-cell fate determinationNature, 2002
- Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem CellsCell, 2001
- Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3aPublished by Elsevier BV ,2000