Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
- 1 August 2004
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 19 (4), 176-182
- https://doi.org/10.1152/physiol.00001.2004
Abstract
The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in Po2 are transduced to effect changes in gene expression.Keywords
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