Determinants for Substrate Specificity of Protein Phosphatase 2A
Open Access
- 2 July 2011
- journal article
- Published by Hindawi Limited in Enzyme Research
- Vol. 2011, 1-8
- https://doi.org/10.4061/2011/398751
Abstract
Protein phosphatase 2A- (PP2A-) catalyzed dephosphorylation of target substrate proteins is widespread and critical for cellular function. PP2A is predominantly found as a heterotrimeric complex of a catalytic subunit (C), a scaffolding subunit (A), and one member of 4 families of regulatory subunits (B). Substrate specificity of the holoenzyme complex is determined by the subcellular locale the complex is confined to, selective incorporation of the B subunit, interactions with endogenous inhibitory proteins, and specific intermolecular interactions between PP2A and target substrates. Here, we discuss recent studies that have advanced our understanding of the molecular determinants for PP2A substrate specificity.Keywords
Funding Information
- National Institutes of Health (NS43254, T32GM067795)
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