Association between abdominal adiposity and 20-year subsequent aortic stiffness in an initially healthy population-based cohort
- 1 October 2018
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal Of Hypertension
- Vol. 36 (10), 2077-2084
- https://doi.org/10.1097/hjh.0000000000001796
Abstract
Aortic stiffness is a feature of arterial aging and is associated with dismal cardiovascular prognosis. We examined whether central and general adiposity is an independent predictor of accelerated aortic stiffening 20 years later in initially healthy midlife individuals. Participants from the STANISLAS cohort study (826 initially healthy participants aged 30–60 from the Lorraine region in France) underwent clinical and biological measurements at baseline (1994–1995) and after ≈20 years (2011–2016). Adiposity measurements included waist circumference/BMI ratio, BMI, waist circumference, and ‘body shape index’ [waist circumference/(BMI2/3 height1/2)]. Real carotid–femoral pulse wave velocity (cfPWV) was measured at end of follow-up. Our primary analysis was to test the association between waist circumference/BMI ratio and cfPWV. In a multiple linear regression model adjusted for sex, age and mean arterial pressure, waist circumference -to-BMI ratio was positively associated (for 1SD increase) with higher cfPWV [regression coefficient β = 0.32, 95% confidence interval (CI) 0.19–0.45, P < 0.001]. The cfPWV was less strongly associated with body shape index (β = 0.17, 95% CI 0.022–0.32, P < 0.05) and negatively associated with BMI (−0.20, 95% CI −0.31 to −0.093, P < 0.001) and waist circumference (−0.14, 95% CI −0.28 to 0.00, P < 0.05). Sensitivity analyses demonstrated that the risk of cfPWV associated with waist circumference-to-BMI ratio remained significant after adjustment for heart rate, metabolic risk factors and inflammatory markers. Central adiposity (and more specifically waist circumference-to-BMI ratio) is an independent predictor of 20-year subsequent aortic stiffness in initially healthy midlife subjects.Keywords
This publication has 36 references indexed in Scilit:
- Overall and abdominal obesity indicators had different association with central arterial stiffness and hemodynamics independent of age, sex, blood pressure, glucose, and lipids in Chinese community-dwelling adultsClinical Interventions in Aging, 2013
- The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in womenBMC Cardiovascular Disorders, 2013
- A New Body Shape Index Predicts Mortality Hazard Independently of Body Mass IndexPLOS ONE, 2012
- Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocityJournal Of Hypertension, 2012
- Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensiveBMC Cardiovascular Disorders, 2012
- The relationship between various measures of obesity and arterial stiffness in morbidly obese patientsBMC Cardiovascular Disorders, 2011
- Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’European Heart Journal, 2010
- Computed tomography-based validation of abdominal adiposity measurements from ultrasonography, dual-energy X-ray absorptiometry and anthropometryBritish Journal of Nutrition, 2010
- Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre- and stage-1 hypertensivesJournal of Human Hypertension, 2008
- Pulse Wave Velocity Is an Independent Predictor of the Longitudinal Increase in Systolic Blood Pressure and of Incident Hypertension in the Baltimore Longitudinal Study of AgingJournal of the American College of Cardiology, 2008