Antigen Processing of the Heptavalent Pneumococcal Conjugate Vaccine Carrier Protein CRM197Differs Depending on the Serotype of the Attached Polysaccharide
Open Access
- 1 July 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (7), 4186-4189
- https://doi.org/10.1128/iai.71.7.4186-4189.2003
Abstract
The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM197. Utilizing antigen-processing cells and a CRM197-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM197. Unconjugated CRM197and serotype conjugates 14 and 18C were processed more efficiently.Keywords
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