Initial Emergency Department Diagnosis and Management of Adult Patients with Severe Sepsis and Septic Shock
Open Access
- 27 June 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
- Vol. 20 (1), 41-11
- https://doi.org/10.1186/1757-7241-20-41
Abstract
Severe sepsis is a medical emergency affecting up to 18 million individuals world wide, with an annual incidence of 750,000 in North America alone. Mortality ranges between 28-50% of those individuals stricken by severe sepsis. Sepsis is a time critical illness, requiring early identification and prompt intervention in order to improve outcomes. This observation has led to increased awareness and education in the field of Emergency Medicine; it has also led to the implementation of critical interventions early in the course of patient management, specifically Early-Goal Directed Therapy, and rapid administration of appropriate antimicrobials. This review begins with a brief summary of the pathophysiology of sepsis, and then addresses the fundamental clinical aspects of ED identification and resuscitation of the septic patient.Keywords
This publication has 54 references indexed in Scilit:
- Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol*Critical Care Medicine, 2011
- Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality*Critical Care Medicine, 2011
- The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patientsIntensive Care Medicine, 2010
- Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis TherapyA Randomized Clinical TrialJama-Journal Of The American Medical Association, 2010
- The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*Critical Care Medicine, 2010
- Multicenter Study of Central Venous Oxygen Saturation (ScvO2) as a Predictor of Mortality in Patients With SepsisAnnals of Emergency Medicine, 2010
- Performance of the Mortality in emergency department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shockThe American Journal of Emergency Medicine, 2008
- Improvement in Process of Care and Outcome After a Multicenter Severe Sepsis Educational Program in SpainJama-Journal Of The American Medical Association, 2008
- Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis studyIntensive Care Medicine, 2007
- Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*Critical Care Medicine, 2006