Chronic fatigue is associated with impaired health‐related quality of life in inflammatory bowel disease
- 25 October 2010
- journal article
- research article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 33 (1), 106-114
- https://doi.org/10.1111/j.1365-2036.2010.04498.x
Abstract
Fatigue is reported to reduce health-related quality of life (HRQOL) in chronic diseases. Studies on the importance of fatigue and its implications for the patient's HRQOL in inflammatory bowel disease (IBD) remain scarce and need to be explored. To investigate the influence of chronic fatigue on both generic and disease-specific HRQOL in IBD. Patients in remission, with mild and moderate IBD completed the Fatigue Questionnaire, the Short-Form 36 (SF-36) and the Norwegian version of the Inflammatory Bowel Disease Questionnaire (N-IBDQ). In addition, demographic and clinical variables were obtained. In total, 140 patients were included; the mean age of patients with chronic fatigue was 44.2 years (s.d. = 15.8), that of nonfatigued was 44.7 years (s.d. = 16.0). Ulcerative colitis (UC)/Crohn's disease (CD) = 92/48. Chronic fatigue was associated, after controlling for covariates, with a reduction of HRQOL scores in 6/8 SF-36 dimensions in UC and 5/8 dimensions in CD. In N-IBDQ, chronic fatigue was associated with a reduction of HRQOL in four subdimensions and total score in CD and all dimensions in UC. Fatigue is associated with reduction of HRQOL scores in IBD. The physical HRQOL domains are particularly affected. The impact of fatigue on disability, sick leave, school and work attendance has to be studied further.This publication has 43 references indexed in Scilit:
- Fatigue: a principal contributor to impaired quality of life in ANCA-associated vasculitisRheumatology, 2010
- The Effect of Smoking on Side Effects Among Cancer Patients Throughout Treatment: a URCC CCOP Study of 947 PatientsCancer Epidemiology, Biomarkers & Prevention, 2010
- Pain and inflammatory bowel diseaseInflammatory Bowel Diseases, 2009
- Quality of life in long-term Hodgkin’s disease survivors with chronic fatigueEuropean Journal of Cancer, 2006
- Patients' fears and unmet needs in inflammatory bowel diseaseAlimentary Pharmacology & Therapeutics, 2004
- Poststroke FatigueStroke, 2002
- A simple clinical colitis activity indexGut, 1998
- Development of a fatigue scaleJournal of Psychosomatic Research, 1993
- The MOS 36-ltem Short-Form Health Survey (SF-36)Medical Care, 1992
- A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITYThe Lancet, 1980