Regulation of serotonin release from the intestinal mucosa
- 31 January 1991
- journal article
- review article
- Published by Elsevier BV in Pharmacological Research
- Vol. 23 (1), 13-25
- https://doi.org/10.1016/s1043-6618(05)80101-x
Abstract
In the mammalian intestine serotonin (5-hydroxytryptamine, 5-HT) is present in high concentrations in the enterochromaffin cells. The release of 5-HT from the intestinal mucosa is regulated by a complex pattern of neuronal and humoral inputs to the enterochromaffin cells. The enterochromaffin cells appear to be endowed with different inhibitory (α2-adrenoceptors, GABAA- and GABAB-receptors, histamine H3-receptors, receptors for vasoactive intestinal polypeptide and somatostatin) as well as stimulatory receptors (β-adrenoceptors, muscarine and nicotine receptors). The physiological significance of this complex system of receptors is suggested by experiments which demonstrate that the respective intrinsic neurotransmitters (catecholamines, acetylcholine, GABA and vasoactive intestinal polypeptide) released within the gut are involved in the regulation of the release of 5-HT from the enterochromaffin cells.Keywords
This publication has 51 references indexed in Scilit:
- Multiple types of neuronal calcium channels and their selective modulationTrends in Neurosciences, 1988
- Bipolarity of duodenal enterochromaffin cells in the ratCell and tissue research, 1987
- Local release of monoamines in the gastrointestinal tract: An in vivo study in rabbitsLife Sciences, 1986
- γ-aminobutyric acid in peripheral tissuesLife Sciences, 1985
- GABA evoked ACh release from isolated guinea pig ileumLife Sciences, 1983
- ?-Aminobutyric acid and cholinergic transmission in the guinea-pig ileumNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1983
- 5-HT metabolism in the intestinal wall of the rat—I. The mucosaNeurochemistry International, 1982
- ?2-Adrenoceptors inhibit the cholera-toxin-induced intestinal fluid accumulationNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1982
- Radioautographic study of uptake and storage of indoleamines in the rabbit enterochromaffin cellsNeuroscience Letters, 1981
- Catecholamine-Induced Release of 5–Hydroxytryptamine (5-HT) from Perfused Vasculature of Isolated dog IntestineJournal of Pharmaceutical Sciences, 1966