New Constituents of Sweet Capsicum annuum L. Fruits and Evaluation of Their Biological Activity
- 13 September 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 54 (20), 7508-7516
- https://doi.org/10.1021/jf061404z
Abstract
Four new acyclic diterpene glycosides named capsianosides (1−4), together with 12 known compounds, were isolated from the fresh sweet pepper fruits of Capsicum annuum L., a plant used as a vegetable food, spice, and external medicine. The chemical structures of new natural compounds, as well as their absolute configurations, were established by means of spectroscopic data including infrared, high-resolution mass spectrometry, and one- and two-dimensional nuclear magnetic resonance and by chemical derivatization. The known capsidiol (11) showed bacteriostatic properties in vitro against Helicobacter pylori with a minimum inhibitory concentration (MIC) of 200 μg/mL when compared with the commercial drug metronidazole (MIC, 250 μg/mL). Some purified components were also tested for their antioxidant activities. Keywords: Capsicum annuum L.; Solanaceae; capsianosides; 2D-NMR; Helicobacter pylori; antioxidant activity; liquid chromatographyThis publication has 27 references indexed in Scilit:
- Tetracycline, metronidazole and amoxicillin-metronidazole combinations in proton pump inhibitor-based triple therapies are equally effective as alternative therapies againstHelicobacter pyloriinfectionJournal of Gastroenterology and Hepatology, 2006
- New Sesquiterpenes from Capsicum annuumJournal of Natural Products, 2004
- Antimicrobial furostanol saponins from the seeds of Capsicum annuum L. var. acuminatumJournal of Agricultural and Food Chemistry, 2002
- New Glycosides from Capsicum annuum L. Var. acuminatum. Isolation, Structure Determination, and Biological ActivityJournal of Agricultural and Food Chemistry, 2001
- Helicobacter pylori—in vitrosusceptibility to garlic(Allium sativum)extractNutrition and Cancer, 1997
- Capsaicin as an inhibitor of the growth of the gastric pathogen Helicobacter pyloriFEMS Microbiology Letters, 1997
- Capsidiol: Its role in the resistance of Capsicum annuum to Phytophthora capsiciPhysiologia Plantarum, 1996
- Novel acyclic diterpene glycosides, capsianosides A-F and I-V from Capsicum plants. Solanaceous studies. XVI.CHEMICAL & PHARMACEUTICAL BULLETIN, 1990
- Capsidiol and 1-epicapsidiol: absolute configuration, nmr, and optical spectra of the dibenzoatesCanadian Journal of Chemistry, 1981
- Intramolecular electrostatic stabilization of an SN1 transition stateThe Journal of Organic Chemistry, 1973