Use of Statins and Blood Pressure Control in Treated Hypertensive Patients with Hypercholesterolemia
- 1 April 2000
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Cardiovascular Pharmacology
- Vol. 35 (4), 549-555
- https://doi.org/10.1097/00005344-200004000-00006
Abstract
High serum cholesterol has been frequently reported in patients with arterial hypertension in whom it might influence the blood pressure control. The aim of this study was to compare the extent of blood pressure changes in 41 patients with hypertension and hypercholesterolemia, taking antihypertensive drugs and treated for 3 months with statins (HC-S; pravastatin or simvastatin) and compared with matched controls with high (HC-D; 44) or normal serum cholesterol (NC-D; 45) undergoing antihypertensive treatment combined with dietary treatment alone. After 3 months of follow-up, a greater reduction of systolic (SBP) and diastolic (DBP) blood pressure values was observed in HC-S patients (ΔSBP/DBP, −11.3 ± 3/−10.6 ± 2%) when compared with both HC-D (ΔSBP/DBP, −6.6 ± 2/−6.1 ± 2%; pKeywords
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