Alpha-synuclein’s degradation in vivo
- 1 February 2012
- journal article
- Published by Taylor & Francis Ltd in Autophagy
- Vol. 8 (2), 281-283
- https://doi.org/10.4161/auto.8.2.18938
Abstract
Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of α-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we review our recent study showing that the ubiquitin-proteasome system and the autophagy-lysosomal pathway are differentially involved in α-synuclein's degradation in vivo. We discuss the key findings obtained with our novel in vivo approach and also present a model for the progression of protein aggregation and dysfunctional degradation in Parkinson disease.Keywords
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