Effect of spasmolytic drugs on esophageal foreign bodies
- 1 January 1995
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Dysphagia
- Vol. 10 (2), 126-127
- https://doi.org/10.1007/bf00440084
Abstract
Muscle spasm has been proposed as the cause for esophageal food impaction. The aim was therefore to treat esophageal foreign bodies with spasmolytic drugs influencing both striated and smooth muscles of the esophagus. A multicenter, placebo-controlled, doubleblind study of glucagon and diazepam was undertaken in 43 patients. The foreign body disimpacted in 9 of 24 patients given active substances and in 6 of 19 patients given placebo; there was no significant difference between these two groups. Almost all disimpactions occurred several hours after injection of the drugs. The hypothesis of muscle spasm as an important cause of esophageal obstruction was rejected. Medical therapies for food disimpaction other than spasmolytic drugs have to be investigated.Keywords
This publication has 11 references indexed in Scilit:
- Foreign bodies in the esophagus. A study of causative factorsDysphagia, 1991
- The treatment of acute esophageal food impaction.Radiology, 1983
- Esophageal food impaction: treatment with glucagon.Radiology, 1983
- Treatment of Esophageal Food Impaction-A New Use for GlucagonDrug Intelligence & Clinical Pharmacy, 1982
- [Esophageal food impaction. Treatment by glucagon (author's transl)].1981
- Current Management of Esophageal Foreign BodiesJAMA Otolaryngology–Head & Neck Surgery, 1981
- Radiologic Treatment of Esophageal Food Impaction Using Intravenous GlucagonRadiology, 1977
- Effect of Glucagon on Esophageal Motor FunctionGastroenterology, 1975
- Nature and Kinetics of Inhibition of Lower Esophageal Sphincter Pressure by GlucagonGastroenterology, 1974