Delivery of Antisense Oligonucleotides Using Cholesterol-Modified Sense Dendrimers and Cationic Lipids
- 23 June 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 16 (4), 827-836
- https://doi.org/10.1021/bc050022g
Abstract
Cholesterol modified mono-, di-, and tetrameric oligonucleotides were synthesized and hybridized with antisense oligonucleotides to study their incorporation in cationic liposomes together with the influence of this dendrimeric delivery system on biological activity. Electrostatic interactions seem to play the most important role during complexation with cationic lipids. This oligonucleotide formulation gives a small but significant increase in the inhibition of P-glycoprotein expression in a cellular system.Keywords
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