Candidate-gene approaches for studying complex genetic traits: practical considerations
- 1 May 2002
- journal article
- editorial
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 3 (5), 391-397
- https://doi.org/10.1038/nrg796
Abstract
Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.Keywords
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