Mechanisms of renal damage owing to infection
- 12 May 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Pediatric Nephrology
- Vol. 20 (8), 1043-1053
- https://doi.org/10.1007/s00467-005-1898-5
Abstract
Urinary tract infection (UTI) is a common bacterial illness in children. It is known to be associated with an increased risk of permanent renal cell damage and scarring which may lead to generation of pathological conditions such as hypertension, pre-eclampsia during pregnancy, renal insufficiency, and end-stage kidney disease. The pathophysiology of renal scarring is still obscure, which makes the prevention of renal damage difficult. During acute infection, there are numerous factors that may contribute to tissue damage. Inflammatory responses are activated by host defense mechanisms as well as by specific bacterial virulence factors. Understanding of these complex mechanisms would be helpful to better identify children at high risk of developing renal scarring following UTI.Keywords
This publication has 123 references indexed in Scilit:
- TNF-α and IL-1β–mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cellsKidney International, 2004
- Severe vesicoureteral reflux and chronic renal failure: a condition peculiar to male gender? Data from the Italkid ProjectThe Journal of Pediatrics, 2004
- ACE gene polymorphism and renal scar in children with acute pyelonephritisPediatric Nephrology, 2002
- Renal scarring caused by vesicoureteric reflux and urinary infection: a study in pigsPediatric Nephrology, 2002
- Cytokine Profiles of Pediatric Patients Treated with Antibiotics for Pyelonephritis: Potential Therapeutic ImpactClinical and Diagnostic Laboratory Immunology, 2001
- Nitric Oxide Generation Mediates Lipid A-Induced Oxidant Injury in Renal Proximal TubulesArchives of Biochemistry and Biophysics, 1997
- Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow-upPediatric Radiology, 1994
- Cortical scintigraphy in the evaluation of renal parenchymal changes in children with pyelonephritisThe Journal of Pediatrics, 1994
- Phagocyte recognition of cells undergoing apoptosisImmunology Today, 1993
- P Fimbriae of Uropathogenic Escherichia coli as Multifunctional Adherence OrganellesZentralblatt für Bakteriologie, 1993