Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study
Open Access
- 16 December 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Nephrology
- Vol. 10 (1), 42
- https://doi.org/10.1186/1471-2369-10-42
Abstract
Antibiotics are preferentially delivered via the peritoneal route to treat peritonitis, a major complication of peritoneal dialysis (PD), so that maximal concentrations are delivered at the site of infection. However, drugs administered intraperitoneally can be absorbed into the systemic circulation. Drugs excreted by the kidneys accumulate in PD patients, increasing the risk of toxicity. The aim of this study is to examine a model of gentamicin pharmacokinetics and to develop an intraperitoneal drug dosing regime that maximises bacterial killing and minimises toxicity.This publication has 36 references indexed in Scilit:
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