In vitro controlled release of theophylline from metal–drug complexes
- 27 June 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry B
- Vol. 1 (32), 3879-3882
- https://doi.org/10.1039/c3tb20633e
Abstract
Two new metal–drug complexes constructed from non-toxic zinc and theophylline (TPL), an anti-asthmatic active drug, have been introduced into a release system based on matrices of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (MC). The release rate of TPL from the metal–drug complexes could be controlled by the amount of MC added, and the release mechanism changed from anomalous transport to Fickian diffusion.Keywords
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