Crossing the endothelial barrier during metastasis
Top Cited Papers
- 22 November 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Cancer
- Vol. 13 (12), 858-870
- https://doi.org/10.1038/nrc3628
Abstract
During metastasis, cancer cells disseminate to other parts of the body by entering the bloodstream in a process that is called intravasation. They then extravasate at metastatic sites by attaching to endothelial cells that line blood vessels and crossing the vessel walls of tissues or organs. This Review describes how cancer cells cross the endothelial barrier during extravasation and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process. Identification of the mechanisms that underlie cancer cell extravasation could lead to the development of new therapies to reduce metastasis.Keywords
This publication has 132 references indexed in Scilit:
- Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivoNature Communications, 2012
- Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes MetastasisCancer Cell, 2011
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisNature, 2011
- TGF-β Signaling in Breast Cancer Cell Invasion and Bone MetastasisJournal of Mammary Gland Biology and Neoplasia, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Macrophage Diversity Enhances Tumor Progression and MetastasisCell, 2010
- Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motilityNature, 2009
- Chemokines and the microenvironment in neuroectodermal tumor–host interactionSeminars in Cancer Biology, 2009
- Trans-cellular migration: cell–cell contacts get intimateCurrent Opinion in Cell Biology, 2008
- TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4Cell, 2008