Coagulation-fibrinolysis system and markers of collagen metabolism in lung cancer

Abstract

Background. Evidence suggests that the fibrinolysis system and peritumoral connective tissue play important roles in tumor spread. Methods. In this study, the authors evaluated the following parameters in 30 consecutive patients with lung cancer: thrombin‐antithrombin complex (TAT), cross‐linked fibrin split products D‐dimer (DD), plasmin‐alpha₂‐antiplasmin inhibitor complex (PAP), and two antigens related to connective tissue, the aminoterminal propeptide of type III procollagen (PIIIP) and the 7s domain of type IV collagen (7s‐collagen). Results. Each parameter was increased significantly in the patients with cancer compared with the control subjects. Except for PIIIP, their concentration in blood was elevated to Significantly greater extent in the patients with distant metastases. The PAP concentration correlated well with the plasma concentration of TAT (r = 0.5; P < 0.01) and DD (r = 0.9; P < 0.0001). There was also strong correlation between the serum concentrations of PIIIP and 7s‐collagen (r = 0.7; P < 0.001). In patients with localized disease, DD levels were correlated significantly with those of PIIIP (Spearman rank‐order correlation [r_a] = 0.6; P < 0.025) and 7s‐collagen (r_a = 0.6; P < 0.01). In the group with disseminated metastases, there was significant inverse relationship between serum PAP concentrations and serum concentrations of 7s‐collagen (r_a = −0.6; P < 0.025). Conclusions. These results confirm the presence of subclinical chronic activation of the parameters of intravascular clotting‐fibrinolysis and alterations in the extracellular matrix of patients with lung cancer. These parameters may be useful as indicators of the clinical progression of malignant disease, particularly of lung cancer.