Can increased nuchal translucency in the first trimester of pregnancy predict gestational diabetes mellitus
- 1 January 2005
- journal article
- research article
- Published by Informa UK Limited in Journal of Obstetrics and Gynaecology
- Vol. 25 (6), 579-582
- https://doi.org/10.1080/01443610500231518
Abstract
The current study was designed to evaluate whether increased nuchal translucency can predict gestational diabetes mellitus. This was a prospective observational study. Among the pregnant women at 11–14 weeks of pregnancy who came to our prenatal unit for a first trimester screening test, 389 pregnant women whose nuchal translucency above 95th centile were selected as the study group and 386 age-matched pregnant women whose nuchal translucency were within the normal range were enrolled as a control group. First, subjects underwent a 50 g glucose screening test; if it was positive then a 100 g oral glucose tolerance test was performed. The main outcome measures were the prevalence of gestational diabetes mellitus and impaired glucose tolerance and the number of macrosomic infants. Impaired glucose tolerance was more common in pregnant women whose nuchal translucency was above the 95th centile (p = 0.048). In addition, macrosomic infants were also more common in pregnant women with a fetal nuchal translucency above the 95th centile (p = 0.045). Macrosomia was more common in the study group with gestational diabetes mellitus (p = 0.046). In conclusion, increased nuchal translucency seems to be predictive for impaired glucose tolerance and macrosomia, which are associated with gestational diabetes mellitus.Keywords
This publication has 10 references indexed in Scilit:
- The effect of metabolic control on fetal nuchal translucency in women with insulin‐dependent diabetes: a preliminary studyUltrasound in Obstetrics & Gynecology, 2003
- Pathophysiology of increased nuchal translucency: a review of the literatureHuman Reproduction Update, 2003
- Increased fetal nuchal translucency at 11–14 weeksPrenatal Diagnosis, 2002
- Microvascular Permeability is Increased in Both Types of Diabetes and Correlates Differentially with Serum Levels of Insulin-Like Growth Factor I (IGF-I) and Vascular Endothelial Growth Factor (VEGF)Hormone and Metabolic Research, 2001
- Impaired glucose tolerance associated with adverse pregnancy outcome: A population-based study in southern SwedenAmerican Journal of Obstetrics and Gynecology, 2001
- Is mild gestational hyperglycaemia associated with maternal and neonatal complications? The Diagest Study.Diabetic Medicine, 2000
- Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.Diabetes, 1998
- The prognosis of fetuses with transient nuchal translucency in the first and early second trimesterActa Obstetricia et Gynecologica Scandinavica, 1997
- Consequences of alteration in capillary permeabilityCanadian Journal of Physiology and Pharmacology, 1996
- Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose IntoleranceDiabetes, 1979