Characterization of the Mechanism of Interaction in Ibuprofen‐Eudragit RL100® Coevaporates
- 1 January 2004
- journal article
- Published by Taylor & Francis Ltd in Drug Development and Industrial Pharmacy
- Vol. 30 (3), 277-288
- https://doi.org/10.1081/ddc-120030421
Abstract
The present study is a preliminary exploration of the affinity between a carboxylic model drug, the nonsteroidal antiinflammatory agent ibuprofen (IBU) and Eudragit RL100 (RL) polymer. Due to the presence of a variable amount of quaternary ammonium groups in this matrix, physical and chemical interaction with the carboxylic drug can occur, which reinforces its scant mechanical dispersion in the polymer network and can ultimately affect its release profile in vitro and in vivo. To study these aspects, IBU was mixed at increasing weight ratios and in different chemical forms (free acid, sodium salt, and n-butyl ester), to investigate further the role of the carboxylic group in the interaction with the RL polymer. Therefore, IBU-RL solid dispersions (coevaporates) were obtained and fully characterized in the solid state through spectroscopic, calorimetric, and x-ray diffractometric analyses. The in vitro release pattern of the drug, in the different chemical states, was studied for the coevaporates, compared with drug-RL physical mixtures, along with drug adsorption profiles from aqueous solutions on the surface of the polymer granules.Keywords
This publication has 23 references indexed in Scilit:
- Preparation and Analgesic Activity of Eudragit RS100® Microparticles Containing DiflunisalDrug Delivery, 2001
- Properties of Tablets Containing Granulations of Ibuprofen and an Acrylic Copolymer Prepared by Thermal ProcessesPharmaceutical Development and Technology, 2001
- Compression of Indomethacin Coprecipitates with Polymer Mixtures: Effect of Preparation MethodologyDrug Development and Industrial Pharmacy, 1995
- Size Control of Ibuprofen Microspheres with an Acrylic Polymer by Changing the pH in an Aqueous Dispersion Medium and Its Mechanism.CHEMICAL & PHARMACEUTICAL BULLETIN, 1993
- Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS, by Changing Their Intraparticle Porosity.CHEMICAL & PHARMACEUTICAL BULLETIN, 1992
- Ibuprofen-Loaded Ethylcellulose Microspheres: Analysis of the Matrix Structure by Thermal AnalysisJournal of Pharmaceutical Sciences, 1991
- Physical Characterization and Dissolution Properties of lbuprofen:Eudragit CoprecipitatesJournal of Pharmaceutical Sciences, 1991
- Physical and Chemical Factors Influencing the Release of Drugs from Acrylic Resin FilmsJournal of Pharmaceutical Sciences, 1990
- Sustained release solid dispersions of indomethacin with Eudragit RS and RLInternational Journal of Pharmaceutics, 1989
- Preparation and dissolution pattern of Eudragit RS microcapsules containing ketoprofen.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986