Sibling Aggregation for Psychopathology in Offspring of Opiate Addicts: Effects of Parental Comorbidity
- 1 August 1999
- journal article
- Published by Informa UK Limited in Journal of Clinical Child Psychology
- Vol. 28 (3), 342-348
- https://doi.org/10.1207/s15374424jccp280306
Abstract
Applied a new analytic approach within the high-risk paradigm, the analysis of sibling aggregation, to identify homogeneous subtypes of familial risk for psychopathology and addiction. All sibling pairs participating in a study of offspring of opiate-addicted parents were identified and their aggregation for psychiatric disorders was determined using pairwise odds ratios, an analytic technique used in genetic epidemiology. Sibling aggregation was most notable for depressive and anxiety disorders but only in the presence of comorbid depressive disorders in the parents. Parental comorbid alcoholism did not impact sibling aggregation. We emphasize methodological implications of this approach for addressing issues of phenotypic and etiologic heterogeneity in the study of developmental risk for substance abuse.Keywords
This publication has 11 references indexed in Scilit:
- Diagnostic and Statistical Manual of Mental DisordersPublished by American Psychiatric Association Publishing ,2013
- Psychopathology in Children of Parents With Opiate Dependence and/or Major DepressionJournal of the American Academy of Child & Adolescent Psychiatry, 1998
- Psychopathology among Offspring of Parents with Substance Abuse and/or Anxiety Disorders: A High-risk StudyJournal of Child Psychology and Psychiatry, 1998
- Multiple jeopardy: Risk and protective factors among addicted mothers' offspringDevelopment and Psychopathology, 1998
- Sibling Resemblance for Psychiatric Disorders in Offspring at High and Low Risk for DepressionJournal of Child Psychology and Psychiatry, 1995
- Genetic epidemiologic studies of affective disorders in childhood and adolescenceArchiv Fur Psychiatrie Und Nervenkrankheiten, 1993
- Families at risk for psychopathology: Who becomes affected and why?Development and Psychopathology, 1993
- Best Estimate of Lifetime Psychiatric DiagnosisArchives of General Psychiatry, 1982
- Retrospective Assessment of Prepubertal Major Depression with the Kiddie-SADS-EJournal of the American Academy of Child Psychiatry, 1982
- A Diagnostic InterviewArchives of General Psychiatry, 1978