PPAR-γ: A Thrifty Transcription Factor
Open Access
- 1 January 2003
- journal article
- Published by SAGE Publications in Nuclear Receptor Signaling
- Vol. 1 (1), e006
- https://doi.org/10.1621/nrs.01006
Abstract
The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-γ as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.Keywords
This publication has 9 references indexed in Scilit:
- Nuclear Receptors and the Control of MetabolismAnnual Review of Physiology, 2003
- Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasisTrends in Endocrinology & Metabolism, 2002
- PPARγANDGLUCOSEHOMEOSTASISAnnual Review of Nutrition, 2002
- Nuclear Receptors and Lipid Physiology: Opening the X-FilesScience, 2001
- PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell GrowthPublished by Elsevier BV ,2001
- Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs)Trends in Molecular Medicine, 2001
- Transcriptional regulation of adipogenesisGenes & Development, 2000
- Peroxisome proliferator-activated receptors: three isotypes for a multitude of functionsCurrent Opinion in Biotechnology, 1999
- PPARγ, the ultimate thrifty geneDiabetologia, 1999