Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
Open Access
- 1 January 2002
- journal article
- Published by Springer Science and Business Media LLC in Journal of Biology
- Vol. 1 (2), 10
- https://doi.org/10.1186/1475-4924-1-10
Abstract
No abstract availableKeywords
This publication has 42 references indexed in Scilit:
- Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedGenes & Development, 2002
- Allosteric binding sites on cell-surface receptors: novel targets for drug discoveryNature Reviews Drug Discovery, 2002
- Intrastriatal Injection of Sonic Hedgehog Reduces Behavioral Impairment in a Rat Model of Parkinson's DiseaseExperimental Neurology, 2002
- Hedgehog signaling in animal development: paradigms and principlesGenes & Development, 2001
- Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptorsTrends in Neurosciences, 2001
- Transmembrane Molecular Pump Activity of Niemann-Pick C1 ProteinScience, 2000
- Sonic hedgehog signaling is essential for hair developmentCurrent Biology, 1998
- Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol HomeostasisScience, 1997
- Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionNature, 1996
- Mutations affecting segment number and polarity in DrosophilaNature, 1980